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Analysis by pollster Survation suggests Labour would win a majority of 262 seats.
Analysis and modelling based on more than 40,000 polls shows Labour leading with 456 seats, with the Conservatives just 72.
Meanwhile, a Savanta poll of voting intentions also warned the Conservative party could face “electoral annihilation”, in bad news for Rishi Sunak.
Survation’s model currently shows the Liberal Democrats leading with 56 seats, the Scottish National Party with 37 and Reform UK with 7.
Analysis suggests Plaid Cymru is on track to win two seats, while the Greens will retain Brighton Pavilion.
The Survation study, by campaign group Best for Britain, used multilevel post-stratification (MRP) techniques to model constituency outcomes.
Survation conducted the poll online or over the phone between May 31 and June 13, surveying 42,269 people.
This is the first MRP analysis since Nigel Farage returned to the political frontline.
Interpreting its findings, Survation said: “Following Mr Farage’s announcement that he would become leader of Reform UK, the party’s vote share has increased in national opinion polls, increasing the party’s chances of winning seats.”
“As expected, the Reform Party has made strong gains in areas where the Conservatives have lost the most support and is now the leading party by vote share in seven seats. The Reform Party is now outperforming the Conservatives with 59 seats.”
The Savanta Study The Sunday Telegraph Labour has a 25-point lead, with Sir Keir Starmer’s party on 46%, up two points on the previous week, and the Conservatives on 21%, down four points.
This is the lowest opinion poll rating the Conservative Party has ever achieved under Mr Sunak.
Chris Hopkins, director of political research at Savanta, said: “Our research suggests that this election could very well be the electoral demise of the Conservative party.”
“The hopes of Conservative candidates are being dashed with a growing number of opinion polls showing the party in increasing distress – and the campaign is only half over.”
“There is a real feeling that things could get much worse for the Conservative Party and, with postal votes about to be dropped into millions of letterboxes, Rishi Sunak’s time is already running out.”
Reform UK increased by three points to 13 percent, the Liberal Democrats increased by two points to 11 percent, the Green Party increased by one point to five percent and the Scottish National Party decreased by one point to two percent.
Savanta conducted the survey of 2,045 UK adults between June 12th and 14th.
Additional reporting by the Press Association